Study of a New Once-Weekly Injection for Adults With Obesity

About the Study

This Phase 3 clinical study is evaluating a new investigational medicine that may help support weight loss and improve metabolic health in adults living with obesity, or those who are overweight with a weight-related health condition.

The investigational medicine is given as a once-weekly injection and is designed to work with the body’s natural pathways involved in appetite regulation and energy balance. By supporting these processes, it may help promote sustained weight loss over time.

The purpose of this study is to assess the safety and effectiveness of this investigational treatment when taken over an extended period in adults without type 2 diabetes.

Even if you have not tolerated GLP-1 treatments in the past, you may still be able to take part, as this investigational medication works differently.

Who is it for?

You are 18 years or older

You have a BMI of:

• 30 kg/m² or higher, OR
• 27 kg/m² or higher and have at least one weight-related condition such as:
  • high blood pressure
  • high cholesterol
  • sleep apnea
  • cardiovascular disease

You do not have type 2 diabetes

You have tried to lose weight through diet changes without long-term success

You are not currently taking a GLP-1

You are willing to attend regular clinic visits (some visits may be fasted)

You are willing to self-administer a once-weekly injection (training provided)

You are using reliable contraception (if applicable)

You are able to commit to the full study duration (approximately 70 weeks)

What to Expect During Study Participation

If eligible, you will take part in the study for up to approximately 70 weeks. This includes screening, treatment, and follow-up.

During the study, you will receive a once-weekly subcutaneous (under the skin) injection of either the investigational medicine or a placebo. Participants are randomly assigned to treatment groups. The study is double-blind, meaning you won’t know which treatment you are receiving.

Throughout the study, doctors and nurses will closely monitor your health, body weight, and overall wellbeing through regular check-ups and testing.

Study assessments may include medical history collection, physical examinations, vital signs, ECGs, blood tests (including fasting blood tests at selected visits), BMI and waist circumference measurements, pregnancy testing and contraceptive counselling (if applicable), lifestyle support guidance, nutritional counselling, body composition assessments (DXA scan), questionnaires, and eDiary reporting.

Before enrolling, the study doctor and clinical team will explain the study in detail, including findings from previous research, potential risks and benefits, and what participation involves.

Eligible participants will receive up to $4420 reimbursement for study-related time and travel.