Weight-Loss Study for Adults 18+ With Type 2 Diabetes

About the Study

This study is evaluating a potential new investigational medicine that may help adults living with type 2 diabetes improve blood sugar control and support weight management.

The investigational medicine is given as a once-weekly injection and is designed to work with the body’s natural metabolic processes that regulate blood glucose and appetite. By supporting these pathways, the medicine may help improve long-term glucose control and promote healthier body weight, without replacing current standard care

The purpose of this study is to evaluate how safe and effective the investigational medicine is when taken over a longer period in adults living with type 2 diabetes and obesity or who are overweight.

Who is it for?

• You are 18 years or older
• You have been diagnosed with type 2 diabetes
• You have a BMI of 27 kg/m² or higher
• You are on stable diabetes treatment (diet/exercise or oral medication)
• You have tried to lose weight with diet and exercise without long-term success
• You are willing to attend regular morning, fasted clinic visits
• You are willing to self-administer a once-weekly injection
• You are able to commit to the full study duration (up to 84 weeks)

What to Expect During Study Participation

If suitable, you will take part in the study for up to 84 weeks, including screening, treatment, and a safety follow-up period. The study involves 15 clinic visits and 7 virtual visits, with clinic visits occurring approximately every four weeks. Fasting is required at protocol-specified visits/assessments meaning morning appointments will need to be scheduled. All appointments will take place during clinic business hours Monday to Friday 9am, to 5pm.

During the study, you will receive a once-weekly subcutaneous (under the skin) injection of either the investigational medicine or a placebo. Participants are randomly assigned to treatment groups, and neither you nor the study team will know which treatment you are receiving.

Throughout the study, doctors and nurses will closely monitor your blood glucose levels, body weight, and overall health through regular check-ups and testing.

Study assessments may include physical examinations, vital signs, ECGs, blood tests, urine screening, eye examinations, weight and BMI measurements, functional assessments, pregnancy testing (if applicable), lifestyle support reviews, diabetes education, and professional nutrition counselling.

Before enrolling, the study doctor and clinical team will explain the study in detail, including findings from previous research, potential risks and benefits, and what participation involves.

Suitable participants will receive reimbursement for study-related time and travel.