Obesity is a chronic medical condition that can affect overall health and increase the risk of developing conditions such as high blood pressure, high cholesterol, sleep apnoea, cardiovascular disease, and fatty liver disease.
Researchers are studying an investigational medicine designed to evaluate whether it, when combined with healthy eating and regular physical activity, may help support long-term weight management. This study will examine the investigational medicine's safety, tolerability, and its effects on health and wellbeing over time.
You may be eligible if you:
OR
If eligible, participation in the main study will last approximately 79 weeks, including screening, treatment, and follow-up. Participants who complete the main study may also be eligible to continue into an Open-Label Extension (OLE), where all participants receive the investigational medicine, subject to meeting the study requirements.
Participants will be randomly assigned to receive either the investigational medicine or placebo. Neither participants nor the study team will know which treatment has been assigned during the study.
The study treatment is self-administered once weekly as an injection under the skin using an autoinjector device.
Researchers will closely monitor participants' health, wellbeing, and safety throughout the study. Study procedures may include physical examinations, blood tests, ECGs, body measurements, questionnaires, and other health assessments.
Clinic visits will take place during business hours of 9am–5pm, Monday–Friday. Visit lengths may vary depending on the assessments required at each visit.