Research Study for Adults with Obesity and Associated Health Conditions

About the Study

Obesity is a complex chronic condition that can increase the risk of other health problems, including high blood pressure, high cholesterol, sleep apnoea, heart disease, and type 2 diabetes. Researchers are studying whether two investigational medicines, used together as self-administered injections, can help with weight management.

Who is it for?

You may be eligible if:

• You are 18 years of age or older
• You have BMI 30 or higher, or BMI 27–30 with a weight-related health condition (e.g., high blood pressure, high cholesterol, sleep apnoea, or heart disease)
• You have previously tried to lose weight through diet without long-term success
• You have not used GLP-1 receptor agonists or any weight-loss medications within the past 6 months
• You are willing to attend scheduled study visits and assessments
• You are able to commit to the full study duration (approximately 52 weeks)
• You are able and willing to self-administer subcutaneous injections

What does study participation look like?

If eligible, you will take part in the study for approximately 52 weeks, including screening, treatment, and follow-up.

The study involves 13 clinic visits, with regular health assessments throughout the study period. Visits will need to be completed during our clinic business hours of 9am to 5pm, Monday to Friday.

Participants will receive weekly study injections of either the investigational medicine or placebo. The investigational medicines will be given subcutaneously or under the skin.

Each clinic visit will last approximately 1-2 hours. During these visits, you may undergo several health assessments, including physical examinations, vital signs checks, ECGs, weight measurements, and blood tests. Some visits will require fasting, meaning you will need to avoid food for up to 8 hours beforehand. For this reason, these appointments will be scheduled in the morning.